Fortified Procaine Benzylpenicillin Rau Kev Txhaj Tshuaj

Muaj pes tsawg leeg:
Eeach vial muaj:
Procaine penicillin bp ……………………… 3,000,000 iu
Benzylpenicillin sodium bp ……………… 1,000,000 iu

Kev piav qhia:
Dawb lossis tawm-dawb hmoov hmoov kom tsis muaj menyuam yaus.
Pharmacological kev txiav txim
Penicillin yog cov tshuaj tua kab mob nqaim-spectrum uas ua rau feem ntau ntawm cov kab mob gram-zoo thiab qee qhov gram-negative cocci. cov kab mob tseem ceeb yog staphylococcus, streptococcus, mycobacterium tuberculosis, corynebacterium, clostridium tetanus, actinomycetes, bacillus anthracis, spirochetes, thiab lwm yam. pharmacokinetics tom qab txhaj tshuaj intramuscular ntawm procaine penicillin, nws maj mam nqus tom qab tso penicillin los ntawm lub zos hydrolysis. lub sijhawm siab tshaj plaws ntev dua, cov ntshav nqus qis dua, tab sis cov nyhuv ntev dua li penicillin. Nws tsuas yog txwv rau cov pathogens uas rhiab heev rau penicillin thiab yuav tsum tsis txhob siv los kho kab mob loj. tom qab procaine penicillin thiab penicillin sodium (poov tshuaj) yog sib xyaw rau hauv kev txhaj tshuaj, cov ntshav siab tuaj yeem nce ntxiv nyob rau ib lub sijhawm luv luv, muab ob qho tib si ntev thiab ua haujlwm sai. kev txhaj tshuaj ntau ntawm cov tshuaj procaine penicillin tuaj yeem ua rau procaine lom.

Pharmacodynamics penicillin yog tshuaj tua kab mob bactericidal nrog cov haujlwm muaj zog tiv thaiv kab mob. nws cov kab mob tiv thaiv kab mob tsuas yog ua rau inhibit lub zog ntawm cov kab mob ntawm tes phab ntsa peptidoglycan. cov kab mob sib kis hauv qib loj hlob tau zoo muab faib ua kom ruaj khov, thiab lub xovtooj ntawm tes nyob hauv theem biosynthesis. nyob rau hauv qhov kev txiav txim ntawm penicillin, qhov hluavtaws ntawm peptidoglycan yog thaiv thiab lub xovtooj ntawm tes tsis tuaj yeem tsim, thiab lub cell cell tau tawg thiab tuag raws li kev ua ntawm osmotic siab.

Penicillin yog cov tshuaj tua kab mob nqaim-spectrum uas ua rau feem ntau ntawm cov kab mob gram-zoo thiab qee qhov gram-negative cocci. cov kab mob tseem ceeb yog staphylococcus, streptococcus, mycobacterium tuberculosis, corynebacterium, clostridium tetanus, actinomycetes, bacillus anthracis, spirochetes, thiab lwm yam.
pharmacokinetics tom qab txhaj tshuaj intramuscular ntawm procaine penicillin, nws maj mam nqus tom qab tso penicillin los ntawm lub zos hydrolysis. lub sijhawm siab tshaj plaws ntev dua, cov ntshav nqus qis dua, tab sis cov nyhuv ntev dua li penicillin. Nws tsuas yog txwv rau cov pathogens uas rhiab heev rau penicillin thiab yuav tsum tsis txhob siv los kho kab mob loj. tom qab procaine penicillin thiab penicillin sodium (poov tshuaj) yog sib xyaw rau hauv kev txhaj tshuaj, cov ntshav siab tuaj yeem nce ntxiv nyob rau ib lub sijhawm luv luv, muab ob qho tib si ntev thiab ua haujlwm sai. kev txhaj tshuaj ntau ntawm cov tshuaj procaine penicillin tuaj yeem ua rau procaine lom.

Yeeb Tshuaj Sib Raug
1. Penicillin ua ke nrog aminoglycosides tuaj yeem nce qhov siab ntawm cov tom kawg hauv cov kab mob, yog li nws muaj cov nyhuv synergistic. 
2. Cov kab mob ua haujlwm sai li sai tau xws li macrolides, tetracyclines thiab amide cawv muaj cov kev cuam tshuam ntawm cov kab mob bactericidal ntawm penicillin thiab yuav tsum tsis txhob siv ua ke. 
3. Cov hlau ions hnyav (tshwj xeeb yog tooj liab, zinc, mercury), cawv, kua qaub, iodine, oxidants, txo cov kab mob, hydroxy compound, acid acid glucose txhaj lossis tetracycline hydrochloride txhaj tuaj yeem rhuav tshem cov kev ua ntawm penicillin, uas yog kev sib kis. 
4. Amines thiab penicillins tuaj yeem tsim cov ntsev uas tsis muaj ntxhiab, uas hloov qhov nqus tau. qhov kev sib txuam no tuaj yeem ncua kev nqus ntawm penicillin, xws li procaine penicillin 
5. Thiab qee qhov kev daws teeb meem tshuaj (xws li chlorpromazine hydrochloride, lincomycin hydrochloride, norepinephrine tartrate, oxytetracycline hydrochloride, tetracycline hydrochloride, b vitamins thiab vitamin c) yuav tsum tsis txhob sib xyaw, txwv tsis pub nws tuaj yeem tsim kev ua kom muaj cua sov, ntab los yog dej nag.

Cov Khoom Qhia
Feem ntau siv rau kev kho mob ntev ntev los ntawm kev mob rau penicillin-rhiab, xws li pus hauv lub tsev menyuam rau tus nyuj, mastitis, mob pob txha nyuaj, thiab lwm yam, kuj tau siv rau kev kis mob los ntawm actinomycetes thiab leptospira.
kev siv thiab ntau npaum li cas
Txog kev txhaj tshuaj intramuscular. 
Ib qho koob tshuaj, rau ib lub cev hnyav, 10,000 txog 20 000 units rau nees thiab nyuj; 20,000 txog 30,000 chav nyob rau yaj, npua, nees luav thiab plab hlaub; 30,000 txog 40,000 units rau cov dev thiab miv. ib hnub ib zaug, rau 2-3 hnub. 
ntxiv cov nqi uas tsim nyog ntawm cov dej huv rau kev txhaj tshuaj kom txiav tawm ua ntej siv.

Kev phiv tshuaj
1. Qhov tshwm sim tsis zoo yog kev fab tshuaj, uas tuaj yeem tshwm sim hauv cov tsiaj txhu feem ntau, tab sis qhov tshwm sim muaj tsawg. cov tshuaj tiv thaiv hauv zos yog tsiag ntawv los ntawm mob edema thiab mob ntawm qhov chaw txhaj tshuaj, thiab cov tshuaj tiv thaiv qis qis yog urticaria thiab tawm pob. nyob rau hauv cov mob hnyav, nws yuav ua rau poob siab lossis tuag taus. 
2. Rau qee tus tsiaj, nws tuaj yeem tsim kev sib kis ob zaug ntawm txoj hnyuv thiab.

Ceev faj
1. Cov khoom no tsuas yog siv los kho cov kab mob sib kis mob los ntawm cov kab mob kis tau yooj yim.
2. Nws yog maj mam soluble hauv dej. thaum sib cuag nrog cov kua qaub, alkali lossis oxidant, nws yuav poob sai sai. yog li ntawd, kev txhaj tshuaj yuav tsum npaj kom txhij ua ntej siv.
3. Mob siab rau kev cuam tshuam thiab cuam tshuam nrog lwm cov tshuaj, kom tsis txhob cuam tshuam rau qhov ua tau.
rho sijhawm
Nyuj, yaj, thiab npua: 28days; 
Rau cov mis: 72 teev.

Cia:
Kaw thiab khaws cia rau hauv qhov chaw qhuav.